Protein Wnt-2

Definition:

Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).

References:

[1]. Kyle M Sousa, et al. Wnt2 regulates progenitor proliferation in the developing ventral midbrain. J Biol Chem. 2010 Mar 5;285(10):7246-53. [Content Brief]

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