Proton-coupled zinc antiporter SLC30A2

Definition:

[Isoform 1]: Electroneutral proton-coupled antiporter concentrating zinc ions into a variety of intracellular organelles including endosomes, zymogen granules and mitochondria. Thereby, plays a crucial role in cellular zinc homeostasis to confer upon cells protection against its potential cytotoxicity. Regulates the zinc concentration of milk, through the transport of zinc ions into secretory vesicles of mammary cells. By concentrating zinc ions into lysosomes participates to lysosomal-mediated cell death during early mammary gland involution.; [Isoform 2]: Electroneutral proton-coupled antiporter mediating the efflux of zinc ions through the plasma membrane.

References:

[1]. Stephen R Hennigar, et al. TNFα Post-Translationally Targets ZnT2 to Accumulate Zinc in Lysosomes. J Cell Physiol. 2015 Oct;230(10):2345-50. [Content Brief]

[2]. Young Ah Seo, et al. A histidine-rich motif mediates mitochondrial localization of ZnT2 to modulate mitochondrial function. Am J Physiol Cell Physiol. 2011 Jun;300(6):C1479-89. [Content Brief]

[3]. Veronica Lopez, et al. Zinc transporter-2 (ZnT2) variants are localized to distinct subcellular compartments and functionally transport zinc. Biochem J. 2009 Jul 29;422(1):43-52. [Content Brief]

[4]. Yarden Golan, et al. ZnT2 is an electroneutral proton-coupled vesicular antiporter displaying an apparent stoichiometry of two protons per zinc ion. PLoS Comput Biol. 2019 Mar 20;15(3):e1006882. [Content Brief]

[5]. Inbal Lasry, et al. A dominant negative heterozygous G87R mutation in the zinc transporter, ZnT-2 (SLC30A2), results in transient neonatal zinc deficiency. J Biol Chem. 2012 Aug 24;287(35):29348-61. [Content Brief]

[6]. Winyoo Chowanadisai, et al. Identification of a mutation in SLC30A2 (ZnT-2) in women with low milk zinc concentration that results in transient neonatal zinc deficiency. J Biol Chem. 2006 Dec 22;281(51):39699-707. [Content Brief]

[7]. Yarden Golan, et al. Heterodimerization, altered subcellular localization, and function of multiple zinc transporters in viable cells using bimolecular fluorescence complementation. J Biol Chem. 2015 Apr 3;290(14):9050-63. [Content Brief]

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