Proton-coupled zinc antiporter SLC30A5

Definition:

Together with SLC30A6 forms a functional proton-coupled zinc ion antiporter mediating zinc entry into the lumen of organelles along the secretory pathway. By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis. Through the transport of zinc into secretory granules of pancreatic beta-cells, plays an important role in the storage and secretion of insulin.; [Isoform 2]: Zinc ion:proton antiporter mediating influx and efflux of zinc at the plasma membrane.

References:

[1]. Ehud Ohana, et al. Identification of the Zn2+ binding site and mode of operation of a mammalian Zn2+ transporter. J Biol Chem. 2009 Jun 26;284(26):17677-86. [Content Brief]

[2]. Ruth A Cragg, et al. A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane. J Biol Chem. 2002 Jun 21;277(25):22789-97. [Content Brief]

[3]. Ruth A Valentine, et al. ZnT5 variant B is a bidirectional zinc transporter and mediates zinc uptake in human intestinal Caco-2 cells. J Biol Chem. 2007 May 11;282(19):14389-93. [Content Brief]

[4]. Kaori Ishihara, et al. Zinc transport complexes contribute to the homeostatic maintenance of secretory pathway function in vertebrate cells. J Biol Chem. 2006 Jun 30;281(26):17743-50. [Content Brief]

[5]. Takumi Wagatsuma, et al. Zinc transport via ZNT5-6 and ZNT7 is critical for cell surface glycosylphosphatidylinositol-anchored protein expression. J Biol Chem. 2022 Jun;298(6):102011. [Content Brief]

[6]. Eitan Hoch, et al. Histidine pairing at the metal transport site of mammalian ZnT transporters controls Zn2+ over Cd2+ selectivity. Proc Natl Acad Sci U S A. 2012 May 8;109(19):7202-7. [Content Brief]

[7]. Taiho Kambe, et al. Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells. J Biol Chem. 2002 May 24;277(21):19049-55. [Content Brief]

[8]. Tomoyuki Suzuki, et al. Two different zinc transport complexes of cation diffusion facilitator proteins localized in the secretory pathway operate to activate alkaline phosphatases in vertebrate cells. J Biol Chem. 2005 Sep 2;280(35):30956-62. [Content Brief]

[9]. Tomoyuki Suzuki, et al. Zinc transporters, ZnT5 and ZnT7, are required for the activation of alkaline phosphatases, zinc-requiring enzymes that are glycosylphosphatidylinositol-anchored to the cytoplasmic membrane. J Biol Chem. 2005 Jan 7;280(1):637-43. [Content Brief]

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