Psoriasis

Definition:

Psoriasis (PSORS) is a chronic, immune-mediated inflammatory skin disease, characterized by increased propagation of the epidermis with dilation of dermal capillaries. The major symptoms of psoriasis are itchy, scaly, and flaky skin, swelling, pain, and disfiguring skin lesions. Plaque psoriasis is the most common form. Other forms include flexural, guttate, nail, inverse psoriasis, erythroderma, and psoriatic arthritis.

References:

[1]. Catherine T Jordan, et al. PSORS2 is due to mutations in CARD14. Am J Hum Genet. 2012 May 4;90(5):784-95. [Content Brief]

[2]. K Asumalahti, et al. A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele. Hum Mol Genet. 2000 Jun 12;9(10):1533-42. [Content Brief]

[3]. Karen Limaye, et al. Psoriasis: an overview and update. Nurse Pract. 2015 Mar 12;40(3):23-6. [Content Brief]

[4]. Muhammad Farooq, et al. Mutation analysis of the IL36RN gene in 14 Japanese patients with generalized pustular psoriasis. Hum Mutat. 2013 Jan;34(1):176-83. [Content Brief]

[5]. Niovi Setta-Kaffetzi, et al. AP1S3 mutations are associated with pustular psoriasis and impaired Toll-like receptor 3 trafficking. Am J Hum Genet. 2014 May 1;94(5):790-7. [Content Brief]

[6]. Ulrike Hüffmeier, et al. Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis. Nat Genet. 2010 Nov;42(11):996-9. [Content Brief]

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