Psychosine receptor

Definition:

Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. Plays a role in immune response by maintaining lysosome function and supporting phagocytosis-mediated intracellular bacteria clearance. May have a role in activation-induced cell death or differentiation of T-cells (By similarity).

References:

[1]. D S Im, et al. Identification of a molecular target of psychosine and its role in globoid cell formation. J Cell Biol. 2001 Apr 16;153(2):429-34. [Content Brief]

[2]. Kara G Lassen, et al. Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk. Immunity. 2016 Jun 21;44(6):1392-405. [Content Brief]

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