PTB domain-containing engulfment adapter protein 1

Definition:

May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.

References:

[1]. Robert S Kiss, et al. The lipoprotein receptor-related protein-1 (LRP) adapter protein GULP mediates trafficking of the LRP ligand prosaposin, leading to sphingolipid and free cholesterol accumulation in late endosomes and impaired efflux. J Biol Chem. 2006 Apr 28;281(17):12081-92. [Content Brief]

[2]. Zhong Ma, et al. Regulation of Arf6 and ACAP1 signaling by the PTB-domain-containing adaptor protein GULP. Curr Biol. 2007 Apr 17;17(8):722-7. [Content Brief]

[3]. Q A Liu, et al. Human CED-6 encodes a functional homologue of the Caenorhabditis elegans engulfment protein CED-6. Curr Biol. 1999 Nov 18;9(22):1347-50. [Content Brief]

[4]. E Smits, et al. The human homologue of Caenorhabditis elegans CED-6 specifically promotes phagocytosis of apoptotic cells. Curr Biol. 1999 Nov 18;9(22):1351-4. [Content Brief]

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