Pyrin domain-containing protein 2

Definition:

May play a role in innate immunity by disrupting the interaction between PYCARD and NLRP3, thereby regulating the NLRP3 inflammasome. May also inhibit NF-kappa-B signaling distally by affecting the nuclear accumulation of RELA.

References:

[1]. Felipe Bedoya, et al. Pyrin-only protein 2 modulates NF-kappaB and disrupts ASC:CLR interactions. J Immunol. 2007 Mar 15;178(6):3837-45. [Content Brief]

[2]. Andrea Dorfleutner, et al. Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation. Infect Immun. 2007 Mar;75(3):1484-92. [Content Brief]

[3]. K A Porter, et al. The CLRX.1/NOD24 (NLRP2P) pseudogene codes a functional negative regulator of NF-κB, pyrin-only protein 4. Genes Immun. 2014 Sep;15(6):392-403. [Content Brief]

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