Pyruvate dehydrogenase kinase 1 (PDK1)

Definition:

Pyruvate dehydrogenase kinase 1 (PDK1) is a key regulatory enzyme in glucose metabolism, inactivates the TCA cycle enzyme, pyruvate dehydrogenase (PDH), which converts pyruvate to acetyl-CoA.

References:

[1]. Kim JW, et al. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab. 2006 Mar;3(3):177-85. [Content Brief]

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