Radical S-adenosyl methionine domain-containing protein 2

Definition:

Interferon-inducible antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Catalyzes the conversion of cytidine triphosphate (CTP) to 3'-deoxy-3',4'-didehydro-CTP (ddhCTP) via a SAM-dependent radical mechanism. In turn, ddhCTP acts as a chain terminator for the RNA-dependent RNA polymerases from multiple viruses and directly inhibits viral replication. Therefore, inhibits a wide range of DNA and RNA viruses, including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus (VSV), zika virus, and human immunodeficiency virus (HIV-1). Promotes also TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating 'Lys-63'-linked ubiquitination of IRAK1 by TRAF6. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins.

References:

[1]. Abdul A Waheed, et al. Influenza virus not cRAFTy enough to dodge viperin. Cell Host Microbe. 2007 Aug 16;2(2):71-2. [Content Brief]

[2]. Chunyu Wei, et al. Viperin Inhibits Enterovirus A71 Replication by Interacting with Viral 2C Protein. Viruses. 2018 Dec 26;11(1):13. [Content Brief]

[3]. Anthony S Gizzi, et al. A naturally occurring antiviral ribonucleotide encoded by the human genome. Nature. 2018 Jun;558(7711):610-614. [Content Brief]

[4]. Yukang Yuan, et al. Targeting UBE4A Revives Viperin Protein in Epithelium to Enhance Host Antiviral Defense. Mol Cell. 2020 Feb 20;77(4):734-747.e7. [Content Brief]

[5]. Bénédicte Vanwalscappel, et al. A Viperin Mutant Bearing the K358R Substitution Lost its Anti-ZIKA Virus Activity. Int J Mol Sci. 2019 Mar 29;20(7):1574. [Content Brief]

[6]. Yugen Zhang, et al. Identification and characterization of interferon-induced proteins that inhibit alphavirus replication. J Virol. 2007 Oct;81(20):11246-55. [Content Brief]

[7]. Mark A Rivieccio, et al. TLR3 ligation activates an antiviral response in human fetal astrocytes: a role for viperin/cig5. J Immunol. 2006 Oct 1;177(7):4735-41. [Content Brief]

[8]. Meili Li, et al. The Interaction Mechanism Between Herpes Simplex Virus 1 Glycoprotein D and Host Antiviral Protein Viperin. Front Immunol. 2019 Dec 11;10:2810. [Content Brief]

[9]. Karla J Helbig, et al. Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector. Hepatology. 2005 Sep;42(3):702-10. [Content Brief]

[10]. K C Chin, et al. Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15125-30. [Content Brief]

[11]. Arti B Dumbrepatil, et al. Viperin interacts with the kinase IRAK1 and the E3 ubiquitin ligase TRAF6, coupling innate immune signaling to antiviral ribonucleotide synthesis. J Biol Chem. 2019 Apr 26;294(17):6888-6898. [Content Brief]

[12]. Ella R Hinson, et al. The N-terminal amphipathic alpha-helix of viperin mediates localization to the cytosolic face of the endoplasmic reticulum and inhibits protein secretion. J Biol Chem. 2009 Feb 13;284(7):4705-12. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.