Ras and EF-hand domain-containing protein

Definition:

Binds predominantly GDP, and also GTP. Acts as a dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules.

References:

[1]. Yuxiao Wang, et al. CRACR2a is a calcium-activated dynein adaptor protein that regulates endocytic traffic. J Cell Biol. 2019 May 6;218(5):1619-1633. [Content Brief]

[2]. Mami Shintani, et al. Characterization of Rab45/RASEF containing EF-hand domain and a coiled-coil motif as a self-associating GTPase. Biochem Biophys Res Commun. 2007 Jun 8;357(3):661-7. [Content Brief]

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