Ras-related protein Rab-26

Definition:

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland.

References:

[1]. Chunman Li, et al. Rab26 modulates the cell surface transport of α2-adrenergic receptors from the Golgi. J Biol Chem. 2012 Dec 14;287(51):42784-94. [Content Brief]

[2]. Xiaolin Tian, et al. RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation. Mol Cell Biol. 2010 Mar;30(5):1269-84. [Content Brief]

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