Ras-related protein Rab-43

Definition:

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.

References:

[1]. Selma Y Dejgaard, et al. Rab18 and Rab43 have key roles in ER-Golgi trafficking. J Cell Sci. 2008 Aug 15;121(Pt 16):2768-81. [Content Brief]

[2]. Shintaro Seto, et al. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. Traffic. 2011 Apr;12(4):407-20. [Content Brief]

[3]. Evelyn Fuchs, et al. Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways. J Cell Biol. 2007 Jun 18;177(6):1133-43. [Content Brief]

[4]. Alexander K Haas, et al. Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells. J Cell Sci. 2007 Sep 1;120(Pt 17):2997-3010. [Content Brief]

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