Receptor expression-enhancing protein 1

Definition:

Required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton. May also enhance the cell surface expression of odorant receptors. May play a role in long-term axonal maintenance.

References:

[1]. Julia Falk, et al. Functional mutation analysis provides evidence for a role of REEP1 in lipid droplet biology. Hum Mutat. 2014 Apr;35(4):497-504. [Content Brief]

[2]. Seong H Park, et al. Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network. J Clin Invest. 2010 Apr;120(4):1097-110. [Content Brief]

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