Rhotekin

Definition:

Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures.

References:

[1]. Hidenori Ito, et al. Possible role of Rho/Rhotekin signaling in mammalian septin organization. Oncogene. 2005 Oct 27;24(47):7064-72. [Content Brief]

[2]. Ching-Ann Liu, et al. Rho/Rhotekin-mediated NF-kappaB activation confers resistance to apoptosis. Oncogene. 2004 Nov 18;23(54):8731-42. [Content Brief]

[3]. C Reynaud, et al. The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element. J Biol Chem. 2000 Oct 27;275(43):33962-8. [Content Brief]

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