Riboflavin kinase

Definition:

Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase.

References:

[1]. Benjamin Yazdanpanah, et al. Riboflavin kinase couples TNF receptor 1 to NADPH oxidase. Nature. 2009 Aug 27;460(7259):1159-63. [Content Brief]

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