Ribonuclease H1

Definition:

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II.

References:

[1]. H Wu, et al. Properties of cloned and expressed human RNase H1. J Biol Chem. 1999 Oct 1;274(40):28270-8. [Content Brief]

[2]. Konstantina Skourti-Stathaki, et al. Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination. Mol Cell. 2011 Jun 24;42(6):794-805. [Content Brief]

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