Ribonuclease P/MRP protein subunit POP5

Definition:

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.

References:

[1]. Jian Wu, et al. Cryo-EM Structure of the Human Ribonuclease P Holoenzyme. Cell. 2018 Nov 15;175(5):1393-1404.e11. [Content Brief]

[2]. H van Eenennaam, et al. hPop5, a protein subunit of the human RNase MRP and RNase P endoribonucleases. J Biol Chem. 2001 Aug 24;276(34):31635-41. [Content Brief]

[3]. Katherine C Goldfarb, et al. Targeted CRISPR disruption reveals a role for RNase MRP RNA in human preribosomal RNA processing. Genes Dev. 2017 Jan 1;31(1):59-71. [Content Brief]

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