RNA transcription, translation and transport factor protein

Definition:

RNA-binding protein involved in modulation of mRNA transcription by Polymerase II. Component of the tRNA-splicing ligase complex and is required for tRNA ligation. May be required for RNA transport.; (Microbial infection) In case of infection by influenza virus A (IVA), is involved in viral replication.

References:

[1]. Johannes Popow, et al. Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors. Nature. 2014 Jul 3;511(7507):104-7. [Content Brief]

[2]. Ariel Rodriguez, et al. Cellular human CLE/C14orf166 protein interacts with influenza virus polymerase and is required for viral replication. J Virol. 2011 Nov;85(22):12062-6. [Content Brief]

[3]. Alicia Pérez-González, et al. hCLE/CGI-99, a human protein that interacts with the influenza virus polymerase, is a mRNA transcription modulator. J Mol Biol. 2006 Oct 6;362(5):887-900. [Content Brief]

[4]. Alicia Pérez-González, et al. hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex. PLoS One. 2014 Mar 7;9(3):e90957. [Content Brief]

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