Serine hydroxymethyltransferase (SHMT)

Definition:

Serine hydroxymethyltransferase (SHMT) is a key mitochondrial enzyme in serine catabolism that converts serine to glycine and a one-carbon unit that yields S-adenosyl methionine (SAM) and NADPH through the folic acid and methionine cycles.

References:

[1]. Parsa S, et al. The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing. Nat Cancer. 2020;1:653-664. [Content Brief]

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