Serine/threonine-protein kinase 16

Definition:

Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.

References:

[1]. A E Berson, et al. Identification and characterization of a myristylated and palmitylated serine/threonine protein kinase. Biochem Biophys Res Commun. 1999 Jun 16;259(3):533-8. [Content Brief]

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