Sialic acid synthase

Definition:

Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively.

References:

[1]. Clara D M van Karnebeek, et al. NANS-mediated synthesis of sialic acid is required for brain and skeletal development. Nat Genet. 2016 Jul;48(7):777-84. [Content Brief]

[2]. S M Lawrence, et al. Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero- D-galacto-nononic acid biosynthetic ability. J Biol Chem. 2000 Jun 9;275(23):17869-77. [Content Brief]

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