Signal peptidase complex catalytic subunit SEC11A

Definition:

Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.

References:

[1]. A Manuel Liaci, et al. Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage. Mol Cell. 2021 Oct 7;81(19):3934-3948.e11. [Content Brief]

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