SLCO1B3-SLCO1B7 readthrough transcript protein

Definition:

Mediates the Na(+)-independent uptake of organic anions. Transports the conjugated steroids 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate) or E2G) and dehydroepiandrosterone 3-sulfate (DHEAS) at the smooth endoplasmic reticulum membrane (SER), granting access to metabolizing enzymes. Contributes to the metabolism of bile acids such as taurocholate (cholyltaurine) and lithocholate, by functioning as a doorway between SER and cytosol, thereby decreasing their circulating levels and protecting the organism from their detergent properties. Regulates access or exit of drugs to the SER lumen.

References:

[1]. Vanessa Malagnino, et al. LST-3TM12 is a member of the OATP1B family and a functional transporter. Biochem Pharmacol. 2018 Feb;148:75-87. [Content Brief]

[2]. Henriette E Meyer Zu Schwabedissen, et al. Genetic variants of SLCO1B7 are of relevance for the transport function of OATP1B3-1B7. Pharmacol Res. 2020 Nov;161:105155. [Content Brief]

[3]. Vanessa Malagnino, et al. OATP1B3-1B7 (LST-3TM12) Is a Drug Transporter That Affects Endoplasmic Reticulum Access and the Metabolism of Ezetimibe. Mol Pharmacol. 2019 Aug;96(2):128-137. [Content Brief]

[4]. Vanessa Malagnino, et al. OATP1B3-1B7, a novel organic anion transporting polypeptide, is modulated by FXR ligands and transports bile acids. Am J Physiol Gastrointest Liver Physiol. 2019 Dec 1;317(6):G751-G762. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.