Sodium-dependent organic anion transporter

Definition:

Transports sulfoconjugated steroid hormones from the extracellular compartment into the cytosol in a sodium-dependent manner without hydrolysis. Steroid sulfate hormones are commonly considered to be biologically inactive metabolites, that may be activated by steroid sulfatases into free steroids. May play an important role by delivering sulfoconjugated steroids to specific target cells in reproductive organs (By similarity). May play a role transporting the estriol precursor 16alpha-hydroxydehydroepiandrosterone 3-sulfate (16a-OH-DHEAS) at the fetal blood vessel endothelium. Can also transport other sulfoconjugated molecules such as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes.

References:

[1]. Joachim Geyer, et al. Cloning and functional characterization of human sodium-dependent organic anion transporter (SLC10A6). J Biol Chem. 2007 Jul 6;282(27):19728-41. [Content Brief]

[2]. Daniela Fietz, et al. Membrane transporters for sulfated steroids in the human testis--cellular localization, expression pattern and functional analysis. PLoS One. 2013 May 8;8(5):e62638. [Content Brief]

[3]. Gary Grosser, et al. Transport of steroid 3-sulfates and steroid 17-sulfates by the sodium-dependent organic anion transporter SOAT (SLC10A6). J Steroid Biochem Mol Biol. 2018 May;179:20-25. [Content Brief]

[4]. H Schweigmann, et al. Transport of the placental estriol precursor 16α-hydroxy-dehydroepiandrosterone sulfate (16α-OH-DHEAS) by stably transfected OAT4-, SOAT-, and NTCP-HEK293 cells. J Steroid Biochem Mol Biol. 2014 Sep;143:259-65. [Content Brief]

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