Steroid receptor RNA activator 1

Definition:

Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.

References:

[1]. R B Lanz, et al. A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex. Cell. 1999 Apr 2;97(1):17-27. [Content Brief]

[2]. Rainer B Lanz, et al. Steroid receptor RNA activator stimulates proliferation as well as apoptosis in vivo. Mol Cell Biol. 2003 Oct;23(20):7163-76. [Content Brief]

[3]. S Chooniedass-Kothari, et al. The steroid receptor RNA activator is the first functional RNA encoding a protein. FEBS Lett. 2004 May 21;566(1-3):43-7. [Content Brief]

[4]. Geneviève Deblois, et al. Ligand-independent coactivation of ERalpha AF-1 by steroid receptor RNA activator (SRA) via MAPK activation. J Steroid Biochem Mol Biol. 2003 Jun;85(2-5):123-31. [Content Brief]

[5]. Kevin M Coleman, et al. SRA coactivation of estrogen receptor-alpha is phosphorylation-independent, and enhances 4-hydroxytamoxifen agonist activity. Biochem Biophys Res Commun. 2004 Oct 8;323(1):332-8. [Content Brief]

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