Steroidogenic acute regulatory protein, mitochondrial

Definition:

Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.

References:

[1]. T Sugawara, et al. Human steroidogenic acute regulatory protein: functional activity in COS-1 cells, tissue-specific expression, and mapping of the structural gene to 8p11.2 and a pseudogene to chromosome 13. Proc Natl Acad Sci U S A. 1995 May 23;92(11):4778-82. [Content Brief]

[2]. H S Bose, et al. The pathophysiology and genetics of congenital lipoid adrenal hyperplasia. N Engl J Med. 1996 Dec 19;335(25):1870-8. [Content Brief]

[3]. D Lin, et al. Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis. Science. 1995 Mar 24;267(5205):1828-31. [Content Brief]

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