Structural maintenance of chromosomes protein 4

Definition:

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

References:

[1]. K Kimura, et al. Chromosome condensation by a human condensin complex in Xenopus egg extracts. J Biol Chem. 2001 Feb 23;276(8):5417-20. [Content Brief]

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