Tachykinin-4

Definition:

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility.

References:

[1]. C G Ravina, et al. A role for tachykinins in the regulation of human sperm motility. Hum Reprod. 2007 Jun;22(6):1617-25. [Content Brief]

[2]. Nigel M Page, et al. Characterization of the endokinins: human tachykinins with cardiovascular activity. Proc Natl Acad Sci U S A. 2003 May 13;100(10):6245-50. [Content Brief]

[3]. Rumi Naono, et al. Leucine at the carboxyl-terminal of endokinins C and D contributes to elicitation of the antagonistic effect on substance P in rat pain processing. Brain Res. 2007 Aug 24;1165:71-80. [Content Brief]

[4]. Daisuke Yoshioka, et al. Intrathecal administration of the common carboxyl-terminal decapeptide in endokinin A and endokinin B evokes scratching behavior and thermal hyperalgesia in the rat. Neurosci Lett. 2006 Dec 27;410(3):193-7. [Content Brief]

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