TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

Definition:

Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF5L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state. Functions with MYC to activate target gene expression through RNA polymerase II pause release (By similarity).

References:

[1]. K Struhl, et al. The TAFs in the HAT. Cell. 1998 Jul 10;94(1):1-4. [Content Brief]

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