Tapasin-related protein

Definition:

Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC).

References:

[1]. Giora I Morozov, et al. Interaction of TAPBPR, a tapasin homolog, with MHC-I molecules promotes peptide editing. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E1006-15. [Content Brief]

[2]. Louise H Boyle, et al. Tapasin-related protein TAPBPR is an additional component of the MHC class I presentation pathway. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3465-70. [Content Brief]

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