TATA box-binding protein-associated factor RNA polymerase I subunit B

Definition:

Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.

References:

[1]. H Beckmann, et al. Coactivator and promoter-selective properties of RNA polymerase I TAFs. Science. 1995 Dec 1;270(5241):1506-9. [Content Brief]

[2]. L Comai, et al. Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits. Science. 1994 Dec 23;266(5193):1966-72. [Content Brief]

[3]. Srivatsava Naidu, et al. TAF1B is a TFIIB-like component of the basal transcription machinery for RNA polymerase I. Science. 2011 Sep 16;333(6049):1640-2. [Content Brief]

[4]. Bruce A Knutson, et al. Yeast Rrn7 and human TAF1B are TFIIB-related RNA polymerase I general transcription factors. Science. 2011 Sep 16;333(6049):1637-40. [Content Brief]

[5]. J C Zomerdijk, et al. Assembly of transcriptionally active RNA polymerase I initiation factor SL1 from recombinant subunits. Science. 1994 Dec 23;266(5193):2015-8. [Content Brief]

[6]. J Karsten Friedrich, et al. TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter. J Biol Chem. 2005 Aug 19;280(33):29551-8. [Content Brief]

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