TBC domain-containing protein kinase-like protein

Definition:

Involved in the modulation of mTOR signaling and expression of mTOR complex components. Involved in the regulation of cell proliferation and growth. Involved in the control of actin-cytoskeleton organization.

References:

[1]. Yueli Liu, et al. TBCK influences cell proliferation, cell size and mTOR signaling pathway. PLoS One. 2013 Aug 19;8(8):e71349. [Content Brief]

[2]. Jin Wu, et al. A long type of TBCK is a novel cytoplasmic and mitotic apparatus-associated protein likely suppressing cell proliferation. J Genet Genomics. 2014 Feb 20;41(2):69-72. [Content Brief]

[3]. Elizabeth J Bhoj, et al. Mutations in TBCK, Encoding TBC1-Domain-Containing Kinase, Lead to a Recognizable Syndrome of Intellectual Disability and Hypotonia. Am J Hum Genet. 2016 Apr 7;98(4):782-8. [Content Brief]

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