Telomere zinc finger-associated protein

Definition:

Telomere-binding protein that acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions. Regulates expression of a small subset of genes, including MTFP1. Regulates expression the J and/or S elements in MHC II promoter. Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A.

References:

[1]. Arne Jahn, et al. ZBTB48 is both a vertebrate telomere-binding protein and a transcriptional activator. EMBO Rep. 2017 Jun;18(6):929-946. [Content Brief]

[2]. Julia Su Zhou Li, et al. TZAP: A telomere-associated protein involved in telomere length control. Science. 2017 Feb 10;355(6325):638-641. [Content Brief]

[3]. Jae-Hyeon Yoon, et al. Human Kruppel-related 3 (HKR3) is a novel transcription activator of alternate reading frame (ARF) gene. J Biol Chem. 2014 Feb 14;289(7):4018-31. [Content Brief]

[4]. M Sugawara, et al. A factor that regulates the class II major histocompatibility complex gene DPA is a member of a subfamily of zinc finger proteins that includes a Drosophila developmental control protein. Mol Cell Biol. 1994 Dec;14(12):8438-50. [Content Brief]

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