Tensin-1

Definition:

May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in fibrillar adhesion formation. Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition. Enhances RHOA activation in the presence of DLC1. Plays a role in cell polarization and migration. May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton.

References:

[1]. Yi-Ping Shih, et al. Tensin1 positively regulates RhoA activity through its interaction with DLC1. Biochim Biophys Acta. 2015 Dec;1853(12):3258-65. [Content Brief]

[2]. Molly Brunner, et al. Osteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition. J Cell Biol. 2011 Jul 25;194(2):307-22. [Content Brief]

[3]. Ksenija Bernau, et al. Tensin 1 Is Essential for Myofibroblast Differentiation and Extracellular Matrix Formation. Am J Respir Cell Mol Biol. 2017 Apr;56(4):465-476. [Content Brief]

[4]. Emily H Hall, et al. Tensin1 requires protein phosphatase-1alpha in addition to RhoGAP DLC-1 to control cell polarization, migration, and invasion. J Biol Chem. 2009 Dec 11;284(50):34713-22. [Content Brief]

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