TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Definition:

Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1.; [Isoform 2]: May be an oncogenic factor.

References:

[1]. Tohru Ishitani, et al. Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. EMBO J. 2003 Dec 1;22(23):6277-88. [Content Brief]

[2]. Li Zhang, et al. Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Nature. 2011 Dec 11;481(7380):204-8. [Content Brief]

[3]. Ge Jin, et al. Identification of a human NF-kappaB-activating protein, TAB3. Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2028-33. [Content Brief]

[4]. Atsuhiro Kanayama, et al. TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol Cell. 2004 Aug 27;15(4):535-48. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.