The B cell activating factor (BAFF)/B lymphocyte stimulator (BLyS)

Definition:

The B cell activating factor (BAFF)/B lymphocyte stimulator (BLyS), is a B cell survival factor which supports autoreactive B cells and prevents their deletion. BAFF expression is closely linked with autoimmunity and is enhanced by genetic alterations and viral infections.

References:

[1]. Tamara Möckel, et al. B cell activating factor (BAFF): Structure, functions, autoimmunity and clinical implications in Systemic Lupus Erythematosus (SLE). Autoimmun Rev. 2021 Feb;20(2):102736. [Content Brief]

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