The bromodomain and extraterminal (BET) family

Definition:

The bromodomain and extraterminal domain (BET) family are important transcription regulators. The BET family of proteins consists of four conserved mammalian members (BRD2, BRD3, BRD4, and BRDT) that regulate the expression of many immunity-associated genes and pathways.

References:

[1]. Nian Wang, et al. The BET family in immunity and disease. Signal Transduct Target Ther. 2021 Jan 19;6(1):23. [Content Brief]

[2]. Filippo Spriano, et al. Targeting BET bromodomain proteins in cancer: The example of lymphomas. Pharmacol Ther. 2020 Nov;215:107631. [Content Brief]

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