The human breast cancer resistance protein (BCRP/ABCG2)

Definition:

The human breast cancer resistance protein (BCRP/ABCG2), the second member of the G subfamily of the large The ATP-binding cassette (ABC) transporter superfamily, is an ATP-binding cassette (ABC) efflux transporter. BCRP was initially discovered in multidrug resistant breast cancer cell lines.

References:

[1]. Zhanglin Ni, et al. Structure and function of the human breast cancer resistance protein (BCRP/ABCG2). Curr Drug Metab. 2010 Sep;11(7):603-17. [Content Brief]

[2]. Qingcheng Mao, et al. Role of the breast cancer resistance protein (BCRP/ABCG2) in drug transport--an update. AAPS J. 2015 Jan;17(1):65-82. [Content Brief]

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