The receptor for advanced glycation end products (RAGE)

Definition:

The receptor for advanced glycation end products (RAGE) is a single-transmembrane and multi-ligand pattern recognition receptor of the immunoglobulin protein super family. RAGE is expressed at low levels under normal physiology, but it is highly upregulated under chronic inflammation because of the accumulation of various RAGE ligands. RAGE also is expressed by multiple cell types in the brain and spinal cord that are linked to the pathogenesis of neurovascular and Neurodegenerative diseases (NDDs). RAGE has effect on numerous intracellular signalling mechanisms.

References:

[1]. Uzma Shahab, et al. The receptor for advanced glycation end products: A fuel to pancreatic cancer. Semin Cancer Biol. 2018 Apr;49:37-43. [Content Brief]

[2]. Barry I Hudson, et al. Targeting RAGE Signaling in Inflammatory Disease. Annu Rev Med. 2018 Jan 29;69:349-364. [Content Brief]

[3]. Michael MacLean, et al. The Receptor for Advanced Glycation End Products (RAGE) and DIAPH1: Implications for vascular and neuroinflammatory dysfunction in disorders of the central nervous system. Neurochem Int. 2019 Jun;126:154-164. [Content Brief]

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