The Toll/interleukin-1 (IL-1) receptor (TIR)

Definition:

The Toll/interleukin-1 (IL-1) receptor (TIR) family comprises two groups of transmembrane proteins: the IL-1 receptor (IL-1R) subfamily and the Toll-like receptor (TLR) subfamily. The Toll/IL-1 receptor (TIR) domain is required for initiating intracellular signaling.

References:

[1]. Michael U Martin, et al. Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family. Biochim Biophys Acta. 2002 Nov 11;1592(3):265-80. [Content Brief]

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