TNF super family

Definition:

Tumor necrosis factor superfamily is a superfamily of type II transmembrane proteins, mainly expressed by immune cells, containing TNF homologous domains and forming trimers. TNF is released from the cell membrane by extracellular proteolytic lysis and functions as a cytokine. The TNF superfamily regulates a variety of cellular functions, including immune response and inflammation, as well as proliferation, differentiation, apoptosis, and embryogenesis.

References:

[1]. Flavell RA. The relationship of inflammation and initiation of autoimmune disease: role of TNF super family members. Curr Top Microbiol Immunol. 2002;266:1-9. [Content Brief]

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