TOM1-like protein 2

Definition:

Acts as a MYO6/Myosin VI adapter protein that targets myosin VI to endocytic structures. May also play a role in recruiting clathrin to endosomes. May regulate growth factor-induced mitogenic signaling.

References:

[1]. Yohei Katoh, et al. Recruitment of clathrin onto endosomes by the Tom1-Tollip complex. Biochem Biophys Res Commun. 2006 Mar 3;341(1):143-9. [Content Brief]

[2]. Mélanie Franco, et al. The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors. Mol Cell Biol. 2006 Mar;26(5):1932-47. [Content Brief]

[3]. David A Tumbarello, et al. Autophagy receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome. Nat Cell Biol. 2012 Oct;14(10):1024-35. [Content Brief]

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