Trafficking protein particle complex subunit 12

Definition:

Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores.

References:

[1]. Miroslav P Milev, et al. Mutations in TRAPPC12 Manifest in Progressive Childhood Encephalopathy and Golgi Dysfunction. Am J Hum Genet. 2017 Aug 3;101(2):291-299. [Content Brief]

[2]. Miroslav P Milev, et al. TRAMM/TrappC12 plays a role in chromosome congression, kinetochore stability, and CENP-E recruitment. J Cell Biol. 2015 Apr 27;209(2):221-34. [Content Brief]

[3]. P James Scrivens, et al. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. Mol Biol Cell. 2011 Jun 15;22(12):2083-93. [Content Brief]

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