Transcription factor GATA-5

Definition:

Transcription factor required during cardiovascular development. Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity (By similarity). Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer.

References:

[1]. Dong Wei, et al. GATA5 loss-of-function mutations underlie tetralogy of fallot. Int J Med Sci. 2013;10(1):34-42. [Content Brief]

[2]. Xian-Ling Zhang, et al. GATA5 loss-of-function mutation in familial dilated cardiomyopathy. Int J Mol Med. 2015 Mar;35(3):763-70. [Content Brief]

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