Transcription factor SOX-3

Definition:

Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity).

References:

[1]. Edwina Sutton, et al. Identification of SOX3 as an XX male sex reversal gene in mice and humans. J Clin Invest. 2011 Jan;121(1):328-41. [Content Brief]

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