Transcription factor Sp3

Definition:

Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping.

References:

[1]. H Braun, et al. Transcription factor Sp3 is regulated by acetylation. Nucleic Acids Res. 2001 Dec 15;29(24):4994-5000. [Content Brief]

[2]. Sudhakar Ammanamanchi, et al. Acetylated sp3 is a transcriptional activator. J Biol Chem. 2003 Sep 12;278(37):35775-80. [Content Brief]

[3]. Christian Ehlting, et al. Sp3 is involved in the regulation of SOCS3 gene expression. Biochem J. 2005 May 1;387(Pt 3):737-45. [Content Brief]

[4]. H Ihn, et al. Sp3 is a transcriptional activator of the human alpha2(I) collagen gene. Nucleic Acids Res. 1997 Sep 15;25(18):3712-7. [Content Brief]

[5]. James R Davie, et al. Nuclear organization and chromatin dynamics--Sp1, Sp3 and histone deacetylases. Adv Enzyme Regul. 2008;48:189-208. [Content Brief]

[6]. Bastian Stielow, et al. SUMO-modified Sp3 represses transcription by provoking local heterochromatic gene silencing. EMBO Rep. 2008 Sep;9(9):899-906. [Content Brief]

[7]. Danielle J P Ellis, et al. The modification of Sp3 isoforms by SUMOylation has differential effects on the SRC1A promoter. Gene. 2006 Sep 1;379:68-78. [Content Brief]

[8]. Sarah Ross, et al. SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization. Mol Cell. 2002 Oct;10(4):831-42. [Content Brief]

[9]. Alexandra Sapetschnig, et al. Complexity of translationally controlled transcription factor Sp3 isoform expression. J Biol Chem. 2004 Oct 1;279(40):42095-105. [Content Brief]

[10]. Mary L Spengler, et al. Sumoylation of internally initiated Sp3 isoforms regulates transcriptional repression via a Trichostatin A-insensitive mechanism. Cell Signal. 2005 Feb;17(2):153-66. [Content Brief]

[11]. Leslie G Wooten-Blanks, et al. Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1. FASEB J. 2007 Oct;21(12):3386-97. [Content Brief]

[12]. H Ding, et al. Functional interactions between Sp1 or Sp3 and the helicase-like transcription factor mediate basal expression from the human plasminogen activator inhibitor-1 gene. J Biol Chem. 1999 Jul 9;274(28):19573-80. [Content Brief]

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