Transcriptional-regulating factor 1

Definition:

Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1.

References:

[1]. Seiichiro Fujisaki, et al. Direct binding of TReP-132 with TdT results in reduction of TdT activity. Genes Cells. 2006 Jan;11(1):47-57. [Content Brief]

[2]. F Gizard, et al. A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression. J Biol Chem. 2001 Sep 7;276(36):33881-92. [Content Brief]

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