Translation initiation factor IF-3, mitochondrial

Definition:

IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins.

References:

[1]. Emine Cavdar Koc, et al. Identification of mammalian mitochondrial translational initiation factor 3 and examination of its role in initiation complex formation with natural mRNAs. J Biol Chem. 2002 Sep 20;277(38):35541-9. [Content Brief]

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