Translocator protein 2

Definition:

Cholesterol-binding protein involved in the redistribution of cholesterol from lipid droplets to the endoplasmic reticulum. Required to meet cholesterol demands during erythropoietic differentiation. May play a role in transport processes at the plasma membrane of erythrocytes, including regulating VDAC-mediated ATP export, and import of the heme precursors protoporphyrin IX and 5-aminolevulinic acid.

References:

[1]. Hana Manceau, et al. TSPO2 translocates 5-aminolevulinic acid into human erythroleukemia cells. Biol Cell. 2020 Apr;112(4):113-126. [Content Brief]

[2]. Jinjiang Fan, et al. Translocator protein 2 is involved in cholesterol redistribution during erythropoiesis. J Biol Chem. 2009 Oct 30;284(44):30484-97. [Content Brief]

[3]. Irene Marginedas-Freixa, et al. Human erythrocytes release ATP by a novel pathway involving VDAC oligomerization independent of pannexin-1. Sci Rep. 2018 Jul 30;8(1):11384. [Content Brief]

[4]. I Marginedas-Freixa, et al. TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood. Sci Rep. 2016 Sep 19;6:33516. [Content Brief]

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