Transmembrane and coiled-coil domains protein 1

Definition:

Endoplasmic reticulum membrane protein that promotes endoplasmic reticulum-associated endosome fission. Localizes to contact sites between the endoplasmic reticulum and endosomes and acts by promoting recruitment of the endoplasmic reticulum to endosome tubules for fission. Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane.

References:

[1]. Melissa J Hoyer, et al. A Novel Class of ER Membrane Proteins Regulates ER-Associated Endosome Fission. Cell. 2018 Sep 20;175(1):254-265.e14. [Content Brief]

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